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Two thugs move from drug dealing to more serious crime in a low-budget thriller shot on location in Arizona. Alex (Bill Osco) and Ray (Jason Williams) are two scruffy small-time hoods who are hoping to make a big score on a cocaine deal. However, not long after scoring the drugs in a desert airplane drop, Alex and Ray are ambushed by the police while making their way into town. The crooks kill the cops and steal an ice-cream truck to make their getaway, tossing the driver out the door as they head west. Alex and Ray find they're short on gas and money as they make their way to the dealer eager to buy their dope, and during a stop at a gas station they empty the cash register, kill the attendants and kidnap Karen (Diane Keller) while stealing her boyfriend's car. Both Ray and Alex enjoy tormenting naive Karen, but Ray has sadistic sexual designs on her, which Alex cannot tolerate. Cop Killers was shot under the title Sweet, Mean and Deadly, and featured producer Bill Osco in his first acting role.