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The title of this episode refers to a magical prescription conjured up by Aunt Clara. Samantha would be wise to follow Clara's advice; as the result of exposure to a black Peruvian rose, Sam has lost her magical powers. Even worse, she has broken out in bizarre square blotches (which are supposed to be green, but photograph as black.) Written by Bernard Slade, "Take Two Aspirins and Half a Pint of Porpoise Milk" originally aired on October 21, 1965.