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Sandra Nelson has achieved much screen attention, with a lot of her parts occurring on television series and movies. Cult lovers may recognize her in roles like her guest-starring one on Star Trek Voyager, and she can also be found in smaller parts in more mainstream pieces like the motion picture Life as a House, directed by Irwin Winkler in 2001. Carving out a niche for herself in the genre of drama, much of her experience has been playing roles on the more serious end of the performance scale. Officially a citizen of both the United States and Canada, she speaks fluently both Canadian French and American English. Having gained credited onscreen appearances by the early '90s appearing largely in dramatic roles, much of her experience came through television. In 1992, she was featured on the TV series Highlander, and counterbalanced her dramatic role there with an appearance in the comedy film The Halfback of Notre Dame in 1995. Maternal Instincts, also starring Delta Burke, featured Nelson in a leading role, and marked a professional return to both television and drama, this time in a film with a psychotic tone. In addition to several smaller roles in made-for-TV movies during the mid- to late-'90s, Nelson was featured on the daytime drama The Young and the Restless during the 1997-1998 season. She would also get involved in romantic drama as Marayna in an episode of Star Trek Voyager. As the 20th century came to a close, she could be found emerging more into the feature-length realm, making an appearance in The Dance in 1999. She appeared in Arthur A. Seidelman's modern Western film By Dawn's Early Light, which originally aired on television in 2000. In 2001, she played a small role in the contemplative drama Life as a House, starring Kevin Kline, and Kristin Scott Thomas.