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Academy of Television Arts and Sciences
| Nominated |
Outstanding Lead Actress in a Miniseries or a Movie The Special Relationship |
2010 |
| Nominated |
Outstanding Supporting Actress in a Drama Series In Treatment [TV Series] |
2009 |
Chicago Film Critics Association
| Nominated |
Best Actress American Splendor |
2003 |
Hollywood Foreign Press Association
| Nominated |
Best Performance by an Actress in a Supporting Role in a Motion Picture American Splendor |
2003 |
| Nominated |
Best Supporting Actress in a Series, Miniseries or Motion Picture Made for Television The Special Relationship |
2010 |
Independent Spirit Awards
| Nominated |
Best Supporting Actress The Secret Lives of Dentists |
2003 |
| Won |
Robert Altman Award Synecdoche, New York |
2008 |
National Society of Film Critics
| Won |
Best Actress - Runner-up The Secret Lives of Dentists |
2003 |
New York Film Critics Circle
| Won |
Best Actress American Splendor |
2003 |
| Won |
Best Actress The Secret Lives of Dentists |
2003 |
