- One of Mexico's most popular actors.
- Is the Spanish-language voice of Donkey in Shrek and Shrek 2.
- Has a degree in Film Directing from the Mexican Institute of Cinematography and Theatre, and one in Acting from Televisa's Acting School.
- Hosted the 2009 and 2010 Latin Grammy Awards.
- Landed the role of a Mexican gardener in the 2011 Adam Sandler comedy Jack and Jill after Sandler's staff suggested Derbez for the part.
- Has authored two books on comedy.